The Commodores rallied to come back and defeat the Wildcats 6-2 to take the series.
The Wildcats scored first when JaVon Shelby singled in the third and later scored off a failed pick off attempt by Commodores starter Tyler Ferguson.
Vanderbilt struggled through the first four innings with only one hit, a single from Xavier Turner.
In the fifth inning, John Norwood hit a two-run homer to give the Commodores their first lead of the game.
Vince Conde added to that lead with a RBI-single in the sixth.
Ka' ai Tom brought the lead back to one run in the seventh with a run-scoring single for the Wildcats.
The Commodores came back in the eighth with three runs to secure the win and extend the lead to 6-2.
Vanderbilt will host UT-Martin Tuesday at 6:30 p.m.