Vanderbilt's four game win streak came to an end with a last minute loss to South Carolina 61-57 in Nashville.
Tiffany Mitchell scored with 50 seconds to play to give the 10th ranked Lady Gamecocks the lead for good.
Christina Foggie led the Commodores with 23 points, but missed several free throws in the final moments.
16th ranked Vanderbilt falls to 16-4 overall and 5-2 in Southeastern Conference play.
The Gamecocks improve to 18-2 and 6-1 in the SEC.