Missouri's James Franklin threw for four touchdowns handing Vanderbilt's James Franklin one of his more painful losses in a 51-28 drubbing at Dudley Field.
The Tigers moved to 5-0 while keeping the Commodores winless in the SEC in their first trip to Nashville.
The 51 points was the most scored against a Vanderbilt team since Florida scored 55 in 2010 and it's the most points ever scored against James Franklin as the Commodores head coach.
Vanderbilt is on a bye week before hosting No. 6 Georgia on October 19.