NFL owners voted Tuesday to hold the 50th Super Bowl at the 49ers new facility in the San Francisco Bay area in 2016.
That stadium is due to open in 2014.
San Francisco beat out South Florida for the game after the Florida Legislature did not support the renovation of Sun Life Stadium.
That decision cost the sunshine state twice. The owners also went elsewhere in awarding Super Bowl 51 to Houston in 2017.
Reliant Stadium also hosted the Super Bowl in 2004.