A wrong way driver crashed into a mini van on Interstate 40 at the I-65 split near downtown on Tuesday night.
The accident was reported just after 9 p.m. at the Jefferson Street overpass.
Officials told Nashville's News 2 it appears the driver of the vehicle traveling in the wrong direction was intoxicated.
The victims were transported to an area hospital as a precaution.
No serious injuries were reported.
It was not immediately known when the roadway would reopen to motorists.