Titans wide receiver Marc Mariani broke his leg during Thursday night's preseason game against the Arizona Cardinals at LP Field.
The 25-year-old was carted off the field following the injury during the first quarter.
The Titans drafted Mariani in the 2010 NFL Draft before signing him to a four-year contract.
He went to the 2011 Pro Bowl for the Titans as a wide receiver.
Mariani is expected to be out with his injury for the 2012-2013 season.
He reportedly underwent surgery for a compound fracture Thursday night.